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KMID : 0604620060130020052
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Dongguk Journal of Medicine
2006 Volume.13 No. 2 p.52 ~ p.57
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The Effect of Autologous Serum Eyedrops in the Treatment of Severe Dry Eye Disease
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Lee Jung-Ho
Lee Yong-Kil
Kang Jung-Hoon
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Abstract
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Dry eye disease has the distinctive feature of ocular surface change, as known squamous metaplasia and the stimulating symptoms, although many treatment was applied artificial tears was the basic treatment. Twenty eyes of fourteen severe dry eye patients used preservative-free artificial tears but suffering from persistent corneal epithelial defect were enrolled in this study. They used autologous serum eyedrops for 2 weeks. We evaluated the results of tear film break-up time, subjective symptom scores and fluorescein staining scores before and 2 weeks after treatment. Before treatment, tear film break-up time, subjective symptom scores and fluorescein staining scores were 4.37±1.27 sec, 3.59±0.81, and 3.51±0.94, espectively. Two weeks after treatment, the respective parameters were 7.61±0.53 sec (p<0.001), 1.87±0.55 (p<0.001), and 3.04±1.05 (p<0.001). All results showed improvement in the patients used autologous serum eyedrops after 2 weeks of treatment. Autologous serum eyedrops were considered as the effective treatment of ocular complications with severe dry eye disease.
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KEYWORD
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autologous serum, dry eye syndrome, fluorescein staining score, tear film break-up time
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